Voedingsadvies El MondoResearch Question:
The results of the meta-analyses on the relationship between vitamin D supplementation and reducing fractures are inconsistent. It was therefore carried out this review article.
Swallowing of 800 IU of vitamin D lowers the chances of getting hip fractures and non-vertebral fractures in the elderly?
Study Design:
This overview article contained 11 Rcts with 31022 persons (average age of 76 years, 91% women) with 1111 incidental non-vertebral fractures and hip fractures 3770.
Results and conclusions:
The researchers found that swallowing average 800 IE (20 micrograms) of vitamin D per day the chances of getting hip fractures significantly reduced by 30%. The hazard ratio was 0.70 [95% CI = 0.58-0.86]. Significant is, it can be said with 95% reliability that the reduced risk of 30% was due to swallowing average 800 IU of vitamin D per day.
The researchers found that swallowing average 800 IE (20 micrograms) of vitamin D per day the chances of getting non-vertebral fractures significantly reduced by 14%. The hazard ratio was 0.86 [95% CI = 0.76-0.96]. Significant because 1 was not in the 95% CI of 0.76-0.96.
The researchers found that the daily swallowing of vitamin D (less than 800 IU) compared to not swallow daily of vitamin D the chances of getting hip fractures non-significant reduced by 10%. The hazard ratio was 0.90 [95% CI = 0.80-1.01]. Non-significant is, it cannot be said with 95% reliability that the reduced risk of 10% was due to the daily swallowing of vitamin d. non-significant means no link.
The researchers found that the daily swallowing of vitamin D (less than 800 IU) compared to not swallow daily of vitamin D the chances of getting non-vertebral fractures significantly reduced by 7%. The hazard ratio was 0.93 [95% CI = 0.87-0.99].
The researchers concluded that the daily swallowing of 800 IU of vitamin D per day or more the chance of getting hip fractures and non-vertebral fractures in people 65 years or older did decrease.
Original title:
A Pooled Analysis of Vitamin D Dose Requirements for Fracture Prevention by Bischoff-Ferrari HA, Willett WC, [...], Dawson-Hughes B.
Link:
http://www.nejm.org/doi/full/10.1056/NEJMoa1109617
Additional information about El Mondo:
Scientific studies show that blood to desired values of to get 75-80 nanomol/l 800-1200 IU of vitamin D per day is needed.
40 IU vitamin D equals 1 micrograms of vitamin d. So 1200 IE than 1200/40 = 30 micrograms of vitamin D per day.
Read more about vitamin D vitamin D in the presentation.