Voedingsadvies El MondoResearch Question:
Endothelial dysfunction is an independent Predictor of atherosclerotic heart disease. Niacin (vitamin B3) has the HDL cholesterol-enhancing, antioxidant and anti-inflammatory properties, which help to improve the function of the endothelium. However, there is still a lot of controversy about the effects of niacin on the endothelium-dependent flow-mediated vasodilation as a reliable surrogate of the function of the endothelium. It was therefore carried out this review article.
Improves swallowing niacin the endothelium-dependent flow-mediated vasodilation (vascular wall function)?
Study Design:
This overview article contained 7 Rcts with a total of 441 participants, of which 213 people in the control group.
Results and conclusions:
The researchers found that a Niacin Therapy the endothelium-dependent flow-mediated vasodilation significantly improved [WMD = 1.98%, 95% CI = 0.91%-3.05%, p = 0.0003]. This effect was robust in the sensitivity analysis and larger when the supplementation at least 2000 mg niacin per day amounted to.
The researchers found in the meta-regression no changes in plasma HDL and LDL cholesterol or triglyceride levels and there was no significant effect of a Niacin Therapy on nitroglycerin-mediated dilation.
The researchers concluded that swallowing of niacin (vitamin B3) the vascular function improved.
Original title:
Effect of niacin on endothelial function: A systematic review and meta-analysis of randomized controlled trials by Sahebkar a.
Link:
http://www.ncbi.nlm.nih.gov/pubmed/24391126
Additional information about El Mondo:
An improved vascular function lowers the chances of getting heart disease. Read more about vitamin B3 and heart disease.