Voedingsadvies El MondoResearch Question:
The endothele function of folic acid supplements improve cardiac patients?
Study Design:
This overview article contained 6 Rcts with 191 patients in the folic acid supplementation group and 186 in the placebo group. The majority of the participants was man.
The duration of the replacement ranged from 8 weeks to 4 months.
There was talk of positive publication bias.
Results and conclusions:
The researchers found that folic acid supplements the flow-mediated dilation or FMD [MD = 57.72 μm, 95% CI = 50.14-65.31, p 0.05] significantly improved.
The researchers found that folic acid supplements the plasma homocysteine levels [MD =-3.66 μmol/L, 95% CI,-5.44 to-1.87, 0.05, I2 = 87% p ] significantly improved.
The researchers concluded that 5 mg folic acid per day for a minimum of 4 weeks the flow-mediated dilation improved and reduced the plasma homocysteine levels in patients with coronary artery disease. So has this overview article in the form of a meta-analysis the importance of high-dose folic acid for improving the function of the endothelium underlined. Folic acid should be recommended to patients with coronary artery disease. However, there are more Rcts need to confirm the conclusion of this meta-analysis.
Original title:
Efficacy of folic acid supplementation on endothelial function and plasma homocysteine concentration in coronary artery disease: A meta-analysis of randomized controlled trials By YI X, ZHOU Y, [...], JIANG X.
Link:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991512/
Additional information about El Mondo:
Coronary heart disease are disorders that are caused by abnormalities in the coronary arteries (coronary artery disease). The two best known diagnoses are acute heart attack and angina.
It is through power supply not possible to get daily 5 mg folic acid within. Via PSU is only possible to 0.2-0.3 mg folic acid to get inside.
Find here more studies on folic acid.