Voedingsadvies El MondoResearch Question:
Swallowing of vitamin C lowers cholesterol levels in people with high cholesterol?
Study Design:
This overview article contained 13 Rcts. The age of the participants ranged from 48 to 82 years.
The dosage of vitamin C was not less than 500 mg daily for 3 to 24 weeks.
The participants in the intervention group at the beginning of the study had a cholesterol content of 163.7 mg/dL and in the control group was that 154.6 mg/dL.
There was heterogeneity because the random effect model was used but no publication bias.
Results and conclusions:
The researchers found (in 11 Rcts with 328 people in the intervention group and 310 in the control group, average age was 58.9 years) that taking vitamin C for 10 weeks the LDL cholesterol (bad cholesterol) significantly with 7.9 mg/dL or 5% [95% CI = − 12.3 to − 3.5, p = 0.000] reduced.
Significant is, there is a link at a 95% reliability.
The researchers found (in 12 Rcts with 355 people in the intervention group and 338 in the control group, average age was 60.8 years) that taking vitamin C for 10 weeks the HDL cholesterol (good cholesterol) non-significant with 1.1 mg/dL or 2.3% [95% CI = − 0.2 to 2.3] increased.
Non-significant is, there is no link to a 95% reliability.
The researchers found (in 10 Rcts with 289 people in the intervention group and 270 in the control group, average age was 55.7 years) that taking vitamin C for 8 weeks the triglyceride levels significantly with 20.1 mg/dL or 8.8% [95% CI = − 33.3 to − 6.8, p 0.003] reduced. Significant is, there is a link at a 95% reliability.
The researchers found that taking vitamin C the LDL/HDL ratio with 0.60 or 16.2% reduced. 16.2% reduction corresponds to a reduced chance of 10.2% of getting heart disease.
The researchers found that taking vitamin C the triglycerides/HDL ratio with 0.47 or 9.4% reduced.
The researchers concluded that swallowing of at least 500 mg of vitamin C per day for 8-10 weeks, LDL cholesterol and triglyceride levels of people with high cholesterol levels reduced.
Original title:
Vitamin C supplementation Dar serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of randomized controlled trials by McRae 13 MP.
Link:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682928/
Additional information about El Mondo:
Read more about cholesterol and vitamin C.
It is not possible to use nutrition to get 500 mg of vitamin C within.
Optimal LDL cholesterol is 100 mg/dL.
Cholesterol levels can differ from day to day about 10 percent.
Desired total cholesterol/HDL ratio is below 5: 1; optimal is below 3.5: 1.
LDL cholesterol/HDL ratio is below 5: 1; optimal is below 3.5: 1.
HDL cholesterol/LDL ratio you want is above 0.3; optimal above 0.4.
The cholesterol ratio is a better predictor for heart disease than total cholesterol value.
The higher the LDL cholesterol and triglyceride levels, the higher the risk of heart disease is.
The higher the HDL cholesterol levels, the lower the risk of heart disease is. HDL cholesterol provides transport of cholesterol from the arterial wall to the liver. The higher the HDL-cholesterol, the better is the drainage of excess cholesterol to the liver.