Alfa-caroteen verlaagt de kans op het krijgen van borstkanker

Research Question:
Lowers eating carotenoids at risk of getting breast cancer?

Study Design:
This overview article contained 33 studies.

Results and conclusions:
The researchers found in cohort studies that compared with the lowest intake, reduced the highest intake of Alpha-carotene through feeding the chance of getting breast cancer significantly with 9% [pooled RR = 0.91, 95% CI = 0.85-0.98, p = 0.01]. Significant is, there is a link.

The researchers found in cohort studies that compared with the lowest intake, reduced the highest intake of beta-carotene through feeding the chance of getting breast cancer by 6% non-significant [pooled RR = 0.94, 95% CI = 0.88-1.00, p = 0.05]. Non-significant is, there is no a bandage. Non-significant because RR of 1 sat in the 95% CI of 0.88-1.00.

The researchers found in cohort studies that compared with the lowest intake, reduced the highest intake of total beta-carotene through feeding the chance of getting breast cancer by 5% non-significant [pooled RR = 0.95, 95% CI = 0.90-1.01, p = 0.08]. Non-significant is, there cannot be said with 95% reliability that the reduced risk of 5% was due to eating a lot of beta carotene.

A significant dose dependent connection was in cohort studies found between the highest intake of both beta-carotene and total beta-carotene via power supply [P trend P trend = 0.03 0.01,] and the reduced risk of getting breast cancer.

A significant dose dependent connection was in cohort studies found between the highest intake of both beta-carotene and total beta-carotene via power supply [0.01 0.01, P trend P trend ] and the reduced risk of getting breast cancer.

No significant association was found between beta-cryptoxanthin, lycopene and luteine and/or zeaxanthin and the reduced risk of getting breast cancer.

The researchers concluded that eating Alpha-carotene reduced the chance of getting breast cancer. However, the positive effect of beta carotene to be confirmed.

Original title:
Carotenoids and breast cancer risk: a meta-analysis and meta-regression by Hu F, Yi BW, [...], Zhao Y.

Link:
http://link.springer.com/article/10.1007%2Fs10549-011-1723-8?LI=true

Additional information about El Mondo:
Read more about carotene in the presentation carotenoids.

Why the conclusion found in cohort studies more reliable than in case-control studies can be read in the presentation design.