Voedingsadvies El MondoResearch Question:
There are more and more data and continuing controversy over the effect of folic acid on getting cancer. It was therefore carried out this review article.
Swallowing folic acid supplements increases the chance of getting cancer?
Study Design:
This overview article contained Rcts.
Results and conclusions:
The researchers found in 13 Rcts (n = 49, 406) that taking folic acid supplements, the chance of getting cancer does not significantly with 5% [95% CI = 0.99-1.11, p = 0.13] increased. Not significant is, there is no link to a 95% reliability.
The researchers found in 7 Rcts (n = 33, 824) that taking folic acid supplements, the chances of getting colon cancer does not significantly with 1% [95% CI = 0.82-1.23, p = 0.95] increased. Not significant is, there cannot be said with 95% reliability that swallowing folic acid supplements the chance of getting colon cancer increased by 1%.
The researchers found in 2 Rcts (n = 20, 228) that swallowing folic acid supplements the chance of getting gastrointestinal cancer (excluding colon cancer) with 0% [95% CI = 0.75-1.33, p = 0.99] increased. Not significant because the found p-value of 0.99 is higher than 0.05.
The researchers found in 5 Rcts (n = 27, 65) that swallowing folic acid supplements the chance of getting prostate cancer not significant 17% [95% CI = 0.84-1.62, p = 0.35] increased. Not significant because the risk of 1 sat in the 95% CI of 0.84 and 1.62. The risk of 1 means no risk.
The researchers found in 2 Rcts (n = 20, 228) that swallowing folic acid supplements the chance of getting Genitourinary cancer (with the exception of prostate cancer) is not significantly with 3% [95% CI = 0.75-1.27, p = 0.84] reduced.
The researchers found in 5 Rcts (n = 31, 864) that swallowing folic acid supplements the chances of getting lung cancer with 0% [95% CI = 0.84-1.21, p = 0.97] increased.
The researchers found in 4 Rcts (n = 19, 800) that swallowing folic acid supplements the chance of getting breast cancer is not significantly with 18% [95% CI = 0.63-1.07, p = 0.15] reduced.
The researchers found in 3 Rcts (n = 25, 670) that swallowing folic acid supplements the chance of getting hematologic malignancy not significantly with 13% [95% CI = 0.64-1.17, p = 0.35] reduced.
The researchers found in 6 Rcts (n = 31, 930) that swallowing folic acid supplements do not significantly the chances of dying from cancer by 2% [95% CI = 0.90-1.15, p = 0.81] increased.
The researchers found in 3 Rcts (n = 19, 128) that swallowing folic acid supplements the chance of getting Melanoma (a type of skin cancer) significantly with 53% [95% CI = 0.23-0.94, p = 0.03] reduced. Significant is, there is a link at a 95% reliability.
The researchers concluded that taking folic acid supplements the chance of getting cancer is not increased. However, swallowing folic acid supplements reduced the chance of getting melanoma.
Original title:
Folic acid supplementation and cancer risk: A meta-analysis of randomized controlled trials by Qin X, Cui Y, [...], Wang X.
Link:
http://www.ncbi.nlm.nih.gov/pubmed/23338728
Additional information about El Mondo:
A Melanoma is a type of skin cancer, arising from the pigment cells of the skin (melanocytes). Anywhere in the skin, these melanocytes.
Melanomas are relatively common in people from a year or 40. More often in women than in men. It is very rare that a child will get a melanoma.
When a Melanoma (melanoma literally means: black tumor) is detected at an early stage, the chances of successfully treating large. The treatment consists of a surgical removal of the melanoma, with the chance of cure is greater than 95%.