Groenten en fruit verlagen de kans op dikke darmkanker

Research Question:
Eating fruits and vegetables lowers the chances of getting colon cancer?

Study Design:
This overview article contained 19 cohort studies with 1.5-1.7 million participants, including 11,800-16,000 cases with colon cancer. As a result, there was a statistical power to find a moderate and weak Association.  There was minimal evidence of heterogeneity between the studies but there was no evidence of small study bias.

Results and conclusions:
The researchers found in 11 cohort studies with 1523860 participants, of which 11853 people with colon cancer, that eating lots of fruits and vegetables the chance of getting colon cancer significantly with 8% [95% CI = 0.86-0.99, p = 0.24 for heterogeneity] reduced. Significant is, there is a link at a 95% reliability.

The researchers found in 14 cohort studies with 1558147 participants, of which 14876 people with colon cancer, that eating about 100 grams of fruit per day the chances of getting colon cancer significantly with 10% [95% CI = 0.83-0.98, p = 0.05 for heterogeneity] reduced.
For 600 grams of fruit per day was the reduced risk of 15%.

The researchers found in studies with 1694236 participants, of which 15 cohort 16057 people with colon cancer, that eating 100-200 g of vegetables per day the chances of getting colon cancer significantly with 9% [95% CI = 0.86-0.96, p for heterogeneity = 0.54] reduced.

The researchers found that in the dose-dependent analysis per 100 g of vegetables a day, the chances of getting colon cancer significantly with 2% [95% CI = 0.97-. 99] reduced. The biggest advantage was found between 100 and 200 g of vegetables per day. It hardly took advantage to an intake higher than 200 grams per day.

In the dose-dependent analyses, the researchers found that per 100 grams of fruit per day, the chance of getting colon cancer non-significant with 2% [95% CI = 0.94-. 1.01] reduced. The biggest advantage was found around 100 grams of fruit per day.
Non-significant is, there is no link to a 95% reliability.

However, the researchers found that the reduced risk of getting colon cancer and eating both vegetables [p for non-linear relationship = 0.001] as fruit [p for non-linear relation 0.001] non-linear was.

The researchers concluded that eating fruit both vegetables as the risk of getting colon cancer reduced. However, the relationship was not linear.

Original title:
Nonlinear Reduction in Risk for Colorectal Cancer by Fruit and Vegetable Intake Based on Meta-analysis of Prospective Studies by Aunee D, Lau R, [...], Norat T.

Link:
http://www.gastrojournal.org/article/S0016-5085%2811%2900522-1/fulltext

Additional information about El Mondo:
The recommendation for vegetables is 200-300 grams per day and for fruit is 2-5 pieces per day.