Nutritional Advice El Mondo
Objectives:
Genistein (4',5,7-trihydroxyisoflavone) is a phytoestrogen with potential health benefits in the prevention of cardiovascular disease. However, the evidence regarding its effects on hypertension has not been conclusive. Therefore, this review article has been conducted.
Do genistein supplements reduce blood pressure?
Study design:
This review article included 4 RCTs (4 treatment arms).
Results and conclusions:
The investigators found genistein supplements did not show any significant reduction of systolic blood pressure [WMD = -5.32 mmHg, 95% CI = -14.59 to 3.96] and diastolic blood pressure [WMD = -2.06 mmHg, 95% CI = -6.41 to 2.28] compared to that of the placebo group.
The investigators found, however, subgroup analysis by intervention duration showed that more than 6 months genistein supplementation in metabolic syndrome patients significantly decreased systolic blood pressure [WMD = -13.73 mmHg, 95% CI = -18.10 to -9.37] and diastolic blood pressure [WMD = -5.18 mmHg, 95% CI = -6.62 to -3.74].
The investigators concluded genistein supplementation of more than 6 months reduces blood pressure among metabolic syndrome patients.
Original title:
Effects of genistein on blood pressure: A systematic review and meta-analysis by Hemati N, Asis M, […], Abdollahi M.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/31955737
Additional information of El Mondo:
Find more information/studies on genistein and overweight right here.