Nutritional Advice El Mondo
Objectives:
As the rise in prevalence of allergic diseases worldwide corresponds in time with increasing infant vaccination, it has been hypothesized that childhood vaccination may increase the risk of allergic disease. Therefore, this review article has been conducted.
Does childhood vaccination increase risk of allergic disease?
Study design:
This review article included 35 publications based on cohort studies and 7 publications based on randomized controlled trials (RCTs).
Results and conclusions:
The investigators found from 2 studies, early vaccination with BCG vaccine was associated with a 17%-reduced risk of eczema [RR = 0.83, 95% CI = 0.73 to 0.93, I2 = 0%] but not food allergy or asthma.
The investigators found no association between pertussis vaccine and any allergic outcome based on a single RCT.
The investigators found in cohort studies that childhood measles vaccination was associated with a reduced risk of 35% for eczema [RR = 0.65, 95% CI= 0.47 to 0.90, I2 = 0.0%], 22% for asthma [RR = 0.78, 95% CI = 0.62 to 0.98, I2 = 93.9%] and, with a similar, statistically non-significant reduction in sensitisation [RR = 0.78, 95% CI = 0.61 to 1.01, I2 = 19.4%].
The investigators concluded there is no evidence that childhood vaccination with commonly administered vaccines is associated with increased risk of later allergic disease. However, pooled analysis of both RCTs and cohort studies show that vaccination with BCG and measles vaccines are associated with a reduced risk of eczema.
Original title:
Childhood Vaccination and Allergy: A Systematic Review and Meta-analyses by Navaratna S, Estcourt MJ, […], Lodge CJ.
Link:
https://pubmed.ncbi.nlm.nih.gov/33569761/
Additional information of El Mondo:
Find more information/studies on vaccination and food fortification/malnutrition right here.
The BCG (Bacillus Calmette-Guérin) vaccination is used against tuberculosis.
Pertussis vaccine is a vaccine that protects against whooping cough (pertussis).