Nutritional Advice El Mondo
Objectives:
Type 2 diabetes mellitus is a chronic disease that occurs among the general population. The insulin-lowering and homeostasis model assessment of insulin resistance-improving effects of inulin are unconfirmed. Therefore, this review article has been conducted.
Do inulin supplements improve HOMA-IR, fasting plasma glucose and HbA1c in patients with type 2 diabetes mellitus?
Study design:
This review article included 9 RCTs with a total of 661 participants.
The duration of the interventions ranged from 6 weeks to 12 weeks and the dosage of inulin supplementation ranged from 8.4 g to 10 g per day.
Results and conclusions:
The investigators found inulin supplementation significantly improved fasting plasma glucose [SMD = -0.55, 95% CI = -0.73 to -0.36, p = 0.0], HOMA-IR [SMD = -0.81, 95% CI = -1.59 to -0.03, p = 0.042] and HbA1c [SMD = -0.69, 95% CI = -0.92 to -0.46, p = 0.0] in patients with type 2 diabetes mellitus.
The investigators found, further subgroup analyses revealed a significant role of inulin supplementation for treatment durations ≥8 weeks [p = 0.038 for insulin, p = 0.002 for HOMA-IR, p = 0.032 for fasting plasma glucose, p = 0 for HbA1c] in patients with type 2 diabetes mellitus.
The investigators concluded that daily 8.4-10 grams of inulin supplements for at least 8 weeks improve HOMA-IR, fasting plasma glucose and HbA1c in patients with type 2 diabetes mellitus.
Original title:
Efficacy of inulin supplementation in improving insulin control, HbA1c and HOMA-IR in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials by Zhang W, Tang Y, […], Hu H.
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263925/
Additional information of El Mondo:
Find more information/studies on fiber and diabetes right here.
Inulin is a type of fiber that's found in certain plant foods. Chicory root is the main source of inulin in supplement form.