Micro-nutrients support reduces chronic inflammation in patients with tuberculosis

Afbeelding

Objectives:
Micro-nutrients are closely related to pulmonary tuberculosis (PTB). Most patients with PTB suffer from micro-nutrients deficiency. Therefore, this review article has been conducted.

Do patients with tuberculosis benefit from micro-nutrients support during an anti-tuberculosis treatment?

Study design:
This review article included a total of 13 RCTs with a total of 2,847 participants.
The duration of the experimental group with micro-nutrients support was more than 2 weeks.

Results and conclusions:
The investigators found micro-nutrients support significantly improved sputum smears [OR = 0.16, 95% CI = 0.03 to 0.77].

The investigators found micro-nutrients support significantly improved culture negative conversion rates [MD = -2.36, 95% CI = -4.72 to -0.01].

The investigators found micro-nutrients support significantly increased lymphocytes [MD = 0.20, 95% CI = 0.06 to 0.35].

The investigators found micro-nutrients support significantly decreased leukocytes, neutrophils, CRP and ESR.

The investigators found, however, micro-nutrients support had no impact on body weight, MUAC, haemoglobin, albumin or monocytes [p > 0.05].

The investigators concluded micro-nutrients support reduces chronic inflammation and improves sputum smears or culture conversions to contribute to anti-tuberculosis treatment.

Original title:
The effect of micro-nutrients on malnutrition, immunity and therapeutic effect in patients with pulmonary tuberculosis: A systematic review and meta-analysis of randomised controlled trials by Cai H, Chen L, […], Wang X.

Link:
https://pubmed.ncbi.nlm.nih.gov/33049436/

Additional information of El Mondo:
Find more information/studies on malnutrition right here.