Nutritional Advice El MondoObjectives:
Does niacine supplementation reduce blood lipids levels in patients with type 2 diabetes mellitus?
Study design:
This review article included randomized controlled trials.
The meta-analysis showed the absence of publication bias and any dose-response relations between niacin and effect size.
There was a significant heterogeneity for the impact of niacin on LDL cholesterol and fasting plasma glucose.
Results and conclusions:
The investigators found niacin supplementation significantly increased HDL cholesterol with 0.27 mmol/L [95% CI = 0.24 to 0.30, p 0.001] in patients with type 2 diabetes mellitus.
The investigators found niacin supplementation significantly reduced LDL cholesterol with 0.250 mmol/L [95% CI = -0.47 to -0.03, p 0.05] in patients with type 2 diabetes mellitus.
The investigators found niacin supplementation significantly reduced triglycerides with 0.39 mmol/L [95% CI = -0.43 to -0.34, p 0.001] in patients with type 2 diabetes mellitus.
The investigators found niacin supplementation significantly increased fasting plasma glucose with 0.085 mmol/L [95% CI = 0.029 to 0.141, p 0.05] compared with controls in patients with long term treatment.
The investigators concluded niacin alone or in combination improves lipid abnormalities in patients with type 2 diabetes mellitus, but requires monitoring of glucose in long term treatment.
Original title:
Effect of niacin on lipids and glucose in patients with type 2 diabetes: A meta-analysis of randomized, controlled clinical trials by Ding Y, Li Y and Wen A.
Link:
http://www.ncbi.nlm.nih.gov/pubmed/25306426
Additional information of El Mondo:
Find more information on niacin (vitamin B3) and diabetes.