No correlation between autoimmune disease and HPV vaccine

Objectives:
In the literature conflicting opinions are detectable on the onset of adverse events as autoimmune disease post HPV vaccine and often case reports describes the onset of one of these events, but don’t emerge a clear relationship and we don’t have data to support it. Therefore, this review article has been conducted.

Does HPV vaccine increase risk of autoimmune diseases/disorders?

Study design:
This review article included 6 RCT’s (3 used a bivalent vaccine and 3 a quadrivalent vaccine), comprising 243,289 in vaccine group and 248,820 in control group.

The age of the enrolled subjects in the studies varied from 9 to 26 years and all studies reported the number of subjects who experienced a specific autoimmune disease.

4 of the 6 trials had a Jadad score of 3 or 4 indicating an adequate trial quality.

The most frequent autoimmune diseases observed across the 6 studies were musculoskeletal, CNS conditions and endocrinological conditions.

Results and conclusions:
The investigators found no correlation between autoimmune disorders and HPV vaccines [pooled OR = 1.038, 95% CI = 0.689-1.562].

The investigators concluded there is no correlation between autoimmune disorders and bivalent and quadrivalent HPV vaccines. It's therefore essential to correctly inform the general population in order to try to increase both Italian and international vaccination coverage.

Original title:
HPV vaccine and autoimmune diseases: systematic review and meta-analysis of the literature by Genovese C, LA Fauci V, […], Squeri R.

Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196376/

Additional information of El Mondo:
Find more information/studies on food fortification/malnutrition and vaccination right here.